Mixed micelles loaded with the 5-benzylidenethiazolidine-2,4-dione derivative SKLB023 for efficient treatment of non-alcoholic steatohepatitis
作者: Li YZhang TLiu QZhang JLi RPu SWu TMa LHe J
刊名: International Journal of Nanomedicine, 2019, Vol.Volume 14 , pp.3943-3953
来源数据库: Directory of Open Access Journals
关键词: Phosphatidylcholine-bile salt-mixed micellesBioavailabilitySolubilizing efficiencyNASH
原始语种摘要: Yanping Li,1 Ting Zhang,2 Qinhui Liu,1 Jinhang Zhang,1 Rui Li,1 Shiyun Pu,1 Tong Wu,1 Liang Ma,3 Jinhan He11Laboratory of Clinical Pharmacy and Adverse Drug Reaction; 2Department of Pharmacy; 3Division of Nephrology, Kidney Research Institute, Collaborative Innovation Center of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, People’s Republic of ChinaBackground: SKLB023, a novel 5-benzylidenethiazolidine-2,4-dione based-derivative, specifically inhibits inducible nitric oxide synthase and shows promise for treating non-alcoholic steatohepatitis (NASH). However, its poor water solubility and low bioavailability limits its clinical use. Here the drug was loaded into phosphatidylcholine-bile salt-mixed micelles (PBMM/SKLB023) to overcome these limitations.Methods:...
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影响因子:3.463 (2012)

  • alcoholic 醇的
  • loaded 加负荷的
  • derivative 衍生物
  • Pharmacy 药店
  • fibrosis 纤维化
  • therapeutic 治疗的
  • treating 处理
  • induced 感应的
  • mouse 小鼠
  • efficacy 效验