Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver.
作者: Satoshi SekiguchiKiminori KimuraTomoko ChiyoTakahiro OhtsukiYoshimi TobitaYuko TokunagaFumihiko YasuiKyoko Tsukiyama-KoharaTakaji WakitaToshiyuki TanakaMasayuki MiyasakaKyosuke MizunoYukiko HayashiTsunekazu HishimaKouji MatsushimaMichinori Kohara
刊名: PLoS ONE, 2017, Vol.7 (12)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0051656
原始语种摘要: Chronic hepatitis C, which is caused by infection with the hepatitis C virus (HCV), is a global health problem. Using a mouse model of hepatitis C, we examined the therapeutic effects of a recombinant vaccinia virus (rVV) that encodes an HCV protein. We generated immunocompetent mice that each expressed multiple HCV proteins via a Cre/loxP switching system and established several distinct attenuated rVV strains. The HCV core protein was expressed consistently in the liver after polyinosinic acid-polycytidylic acid injection, and these mice showed chronic hepatitis C-related pathological findings (hepatocyte abnormalities, accumulation of glycogen, steatosis), liver fibrosis, and hepatocellular carcinoma. Immunization with one rVV strain (rVV-N25), which encoded nonstructural HCV proteins,...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • vaccinia 牛痘病
  • hepatitis 肝炎
  • nonstructural 非构造的
  • protein 蛋白质
  • liver 
  • recombinant 重组体
  • mouse 小鼠
  • cytokines 细胞浆移动
  • viral 病毒性的
  • immune 免疫的