Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice.
作者: Natsuko TsujinoTomomi TsunematsuMotokazu UchigashimaKohtarou KonnoAkihiro YamanakaKazuto KobayashiMasahiko WatanabeYoshimasa KoyamaTakeshi Sakurai
刊名: PLoS ONE, 2017, Vol.8 (7)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0070012
原始语种摘要: Narcolepsy patients often suffer from insomnia in addition to excessive daytime sleepiness. Narcoleptic animals also show behavioral instability characterized by frequent transitions between all vigilance states, exhibiting very short bouts of NREM sleep as well as wakefulness. The instability of wakefulness states in narcolepsy is thought to be due to deficiency of orexins, neuropeptides produced in the lateral hypothalamic neurons, which play a highly important role in maintaining wakefulness. However, the mechanism responsible for sleep instability in this disorder remains to be elucidated. Because firing of orexin neurons ceases during sleep in healthy animals, deficiency of orexins does not explain the abnormality of sleep. We hypothesized that chronic compensatory changes in the...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • wakefulness 警醒症
  • sleep 睡眠
  • narcolepsy 发自睡病
  • coeruleus 天蓝色
  • neuron 神经元
  • insomnia 失眠
  • serotonergic 含血清素的
  • locus 轨迹
  • monoaminergic 单胺能的
  • daytime 白天