Clinical efficacy of first-generation EGFR-TKIs in patients with advanced non-small-cell lung cancer harboring EGFR exon 20 mutations
作者: Chen DSong ZCheng G
刊名: OncoTargets and Therapy, 2016, Vol.2016 (Issue 1), pp.4181-4186
来源数据库: Directory of Open Access Journals
关键词: Non-small cell lung cancerEpidermal growth factor receptorEGFR mutationsExon20Tyrosine kinase inhibitor
原始语种摘要: Dan Chen,1 Zhengbo Song,2 Guoping Cheng3 1Department of Cardiothoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 2Department of Chemotherapy, 3Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China Purpose: Subsets of non-small-cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations carry uncommon subtypes. We evaluated the efficacy of first-generation EGFR-tyrosine kinase inhibitors (TKIs; erlotinib, gefitinib, and icotinib) in patients with non-small-cell lung cancer carrying insertions and T790M and S768I mutations in EGFR exon 20. Patients and methods: Patients carrying EGFR exon 20 insertion/T790M/S768I mutations and treated with EGFR-TKIs were evaluated from 2005 to 2014 in Zhejiang...
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影响因子:2.073 (2012)

  • efficacy 效验
  • generation 世代
  • cancer 癌症
  • small 小的
  • uncommon 非常的
  • epidermal 上皮的
  • survival 生存
  • receptor 接受体
  • factor 因素
  • growth 生长