Overexpression of EMMPRIN isoform 2 is associated with head and neck cancer metastasis.
作者: Zhiquan HuangNing TanWeijie GuoLili WangHaigang LiTianyu ZhangXiaojia LiuQin XuJinsong LiZhongmin Guo
刊名: PLoS ONE, 2017, Vol.9 (4)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0091596
原始语种摘要: Extracellular matrix metalloproteinase inducer (EMMPRIN), a plasma membrane protein of the immunoglobulin (Ig) superfamily, has been reported to promote cancer cell invasion and metastasis in several human malignancies. However, the roles of the different EMMPRIN isoforms and their associated mechanisms in head and neck cancer progression remain unknown. Using quantitative real-time PCR, we found that EMMPRIN isoform 2 (EMMPRIN-2) was the only isoform that was overexpressed in both head and neck cancer tissues and cell lines and that it was associated with head and neck cancer metastasis. To determine the effects of EMMPRIN-2 on head and neck cancer progression, we transfected head and neck cancer cells with an EMMPRIN-2 expression vector and EMMPRIN-2 siRNA to exogenously modulate...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • metastasis 同质蜕变
  • cancer 癌症
  • associated 相关的
  • promote 助长
  • tumorigenesis 瘤形成
  • invasion 侵入
  • adhesion 粘附
  • demonstrated 探明的储量
  • migration 迁移
  • enhanced 增强