A review of analytical methods for the determination of four new phosphodiesterase type 5 inhibitors in biological samples and pharmaceutical preparations
作者: Cristiane Franco CodevillaTamara dos Santos CastilhosAna Maria Bergold
刊名: Brazilian Journal of Pharmaceutical Sciences, 2013, Vol.49 (1), pp.1-11
来源数据库: Directory of Open Access Journals
关键词: Inibidores da fosfodiesterase tipo 5Inibidores da fosfodiesterase tipo 5Inibidores da fosfodiesterase tipo 5Inibidores da fosfodiesterase tipo 5Métodos analíticosDisfunção erétilPhosphodiesterase type 5 inhibitorsPhosphodiesterase type 5 inhibitorsPhosphodiesterase type 5 inhibitorsPhosphodiesterase type 5 inhibitorsAnalytical methodsErectile dysfunction
原始语种摘要: The introduction of oral phosphodiesterase type 5 inhibitor therapy in 1998 revolutionized the treatment of erectile dysfunction. Erectile dysfunction is the most common sexual problem in men. It often has a profound effect on intimate relationships and quality of life. The analysis of pharmaceuticals is an important part of the drug development process as well as for routine analysis and quality control of commercial formulations. Whereas the determination of sildenafil citrate, vardenafil and tadalafil are well documented by a variety of methods, there are few publications about the determination of udenafil, lodenafil carbonate, mirodenafil and avanafil. The paper presents a brief review of the action mechanism, adverse effects, pharmacokinetics and the most recent analytical methods...
全文获取路径: DOAJ  (合作)
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关键词翻译
关键词翻译
  • biological 生物学的
  • analytical 分析的
  • determination 测定
  • effects 海员自身物品
  • quality 品质
  • introduction 导言
  • treatment 处理
  • pharmaceutical 
  • sexual 两性的
  • carbonato 含碳酸盐的