Is the Cell Nucleus a Necessary Component in Precise Temporal Patterning?
作者: Jaroslav AlbertMarianne Rooman
刊名: PLoS ONE, 2017, Vol.10 (7)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0134239
原始语种摘要: One of the functions of the cell nucleus is to help regulate gene expression by controlling molecular traffic across the nuclear envelope. Here we investigate, via stochastic simulation, what effects, if any, does segregation of a system into the nuclear and cytoplasmic compartments have on the stochastic properties of a motif with a negative feedback. One of the effects of the nuclear barrier is to delay the nuclear protein concentration, allowing it to behave in a switch-like manner. We found that this delay, defined as the time for the nuclear protein concentration to reach a certain threshold, has an extremely narrow distribution. To show this, we considered two models. In the first one, the proteins could diffuse freely from cytoplasm to nucleus (simple model); and in the second one,...
全文获取路径: DOAJ  (合作)
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来源刊物:
影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • proteins 蛋白质
  • prokaryotic 原核生物的
  • nuclear 原子核的
  • concentration 浓度
  • eukaryotic 真核的
  • contained 容纳的
  • cytoplasmic 细胞质的
  • motif 花纹图案
  • nucleus 晶核
  • genetic 遗传的