Novel feature for catalytic protein residues reflecting interactions with other residues.
作者: Yizhou LiGongbing LiZhining WenHui YinMei HuJiamin XiaoMenglong Li
刊名: PLoS ONE, 2017, Vol.6 (3)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0016932
原始语种摘要: Owing to their potential for systematic analysis, complex networks have been widely used in proteomics. Representing a protein structure as a topology network provides novel insight into understanding protein folding mechanisms, stability and function. Here, we develop a new feature to reveal correlations between residues using a protein structure network. In an original attempt to quantify the effects of several key residues on catalytic residues, a power function was used to model interactions between residues. The results indicate that focusing on a few residues is a feasible approach to identifying catalytic residues. The spatial environment surrounding a catalytic residue was analyzed in a layered manner. We present evidence that correlation between residues is related to their...
全文获取路径: DOAJ  (合作)
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来源刊物:
影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • residues 残余物
  • catalytic 催化的
  • feature 结构元件
  • protein 蛋白质
  • reveal 显露
  • layered 成层的
  • reflecting 反映的
  • dependence 从属
  • focusing 
  • structure 构造