Virological outcomes and drug resistance in Chinese patients after 12 months of 3TC-based first-line antiretroviral treatment, 2011-2012.
作者: Jing WangCui HeJenny H HsiXiaoqin XuYong LiuJianmei HeHua LingPing DingYi TongXiaobai ZouQuanhua ZhouLingjie LiaoXia WangYuhua RuanYiming ShaoHui Xing
刊名: PLoS ONE, 2017, Vol.9 (2)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0088305
原始语种摘要: OBJECTIVE: To determine the prevalence of virological failure and HIV drug resistance among Chinese patients one year after initiating lamivudine-based first-line antiretroviral treatment. METHODS: A prospective cohort study with follow-up at 12 months was conducted in four urban sentinel sites in China. Antiretroviral naive patients ≥18 years old were recruited. Blood samples were collected for testing CD4 cell count, viral load, and (for samples with HIV-1 RNA ≥1000 copies/ml) genotyping of drug resistance. RESULTS: A total of 513 patients were enrolled in this cohort, of whom 448 (87.3%) were retained at 12 months. The median final CD4 cell count was 313 cells/mm(3), which increased from 192 cells/mm(3) at baseline (P<0.0001). Of the 448 remaining subjects, 394 (87.9%) had successful...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • HIV Hydraulic Isolation Valve
  • treatment 处理
  • resistance 抵抗
  • first 第一
  • cohort 伙伴
  • sentinel 标志
  • cells 麻风细胞
  • count 计数
  • negatively 否定地
  • missed 未达到的