Antimicrobial effect of para-alkoxyphenylcarbamic acid esters containing substituted N-phenylpiperazine moiety
作者: Ivan MalíkMarián BukovskýFils AndriamaintyJana Gališinová
作者单位: 1Comenius University
刊名: Brazilian Journal of Microbiology, 2013, Vol.44 (2), pp.457-463
来源数据库: Directory of Open Access Journals
DOI: 10.1590/S1517-83822013000200018
关键词: PhenylcarbamatesSubstituted N-phenylpiperazinesCandida albicans
原始语种摘要: In current research, nine basic esters of para-alkoxyphenylcarbamic acid with incorporated 4-(4fluoro-/3-trifluoromethylphenyl)piperazin-1-yl fragment, 6i-6m and 8f-8i, were screened for their in vitro antimicrobial activity against Candida albicans, Staphylococcus aureus and Escherichia coli, respectively. Taking into account the minimum inhibitory concentration assay (MIC), as the most active against given yeast was evaluated 8i (MIC = 0.20 mg/mL), the most lipophilic structure containing para-butoxy and trifluoromethyl substituents. Investigating the efficiency of the compounds bearing only a single atom of fluorine and appropriate para-alkoxy side chain against Candida albicans, the cut-off effect was observed. From evaluated homological series, the maximum of the effectiveness was...
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  • esters 酯类
  • moiety 一部分
  • substituted 取代的
  • incorporated 股份有限公司
  • alkoxy 烷氧基
  • effect 效应
  • homological 相应的
  • Candida 坎迪德
  • fluorine 
  • fluoro 氟代