T cellderived lymphotoxin limits Th1 response during HSV1 infection
作者: Kaiting YangYong LiangZhichen SunLongchao LiuJing LiaoHairong XuMingzhao ZhuYang-Xin FuHua Peng
刊名: Scientific Reports, 2018, Vol.8 (1), pp.1-9
来源数据库: Directory of Open Access Journals
DOI: 10.1038/s41598-018-36012-z
原始语种摘要: Abstract Though lymphotoxin (LT is highly expressed by type I helper T (Th1 cells, its contribution to CD4+ T cell differentiation during infections and diseases remains a mystery. In HSV-1 infection, we observed that LTβR signaling is required to limit the Th1 response. Using bone marrow chimeric mice, mixed-T-cell chimeric mice, and LTβR in vivo blockades, we unexpectedly observed that LT, especially T cell-derived LT, played an indispensable role in limiting the Th1 response. Thexa0LTβR-Ig blockade promoted the Th1 response by increasing infiltration of monocytes and monocyte-derived DCs and up-regulating IL-12xa0secretion in the lymphoid environment. Our findings identified a novel role for T cell-derived LT in manipulating Th1 differentiation.
全文获取路径: DOAJ  (合作)
影响因子:2.927 (2012)

  • lymphotoxin 淋巴细胞毒素
  • infection 感染
  • response 响应
  • helper 助手
  • remains 残渣
  • derived 导生的
  • monocyte 单核细胞
  • secretion 分泌
  • observed 观察到的
  • limits 范围