Seasonality modifies methylation profiles in healthy people.
作者: Fulvio RicceriMorena TrevisanValentina FianoChiara GrassoFrancesca FasanelliChiara ScocciantiLaura De MarcoAnna Gillio TosPaolo VineisCarlotta Sacerdote
刊名: PLoS ONE, 2017, Vol.9 (9)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0106846
原始语种摘要: DNA methylation is a well-characterized epigenetic modification that plays an important role in the regulation of gene expression. There is growing evidence on the involvement of epigenetic mechanisms in disease onset, including cancer. Environmental factors seem to induce changes in DNA methylation affecting human health. However, little is known about basal methylation levels in healthy people and about the correlation between environmental factors and different methylation profiles. We investigated the effect of seasonality on basal methylation by testing methylation levels in the long interspersed nucleotide element-1 (LINE-1) and in two cancer-related genes (RASSF1A and MGMT) of 88 healthy male heavy smokers involved in an Italian randomized study; at enrolment the subjects donated a...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • methylation 甲基化酌
  • percentage 百分数
  • growing 饲育
  • people 民族
  • healthy 健康的
  • basal 基部
  • observation 观测
  • epigenetic 后成的
  • collected 收帐
  • respectively 分别