LIPH expression in skin and hair follicles of normal coat and Rex rabbits.
作者: Mathieu DiribarneXavier MataJulie RivièreStéphan BouetAnne VaimanJérôme ChapuisFabienne ReineRenaud FleurotGérard AuvinetSéverine DeretzDaniel AllainLaurent SchiblerEdmond-Paul CribiuGérard Guérin
刊名: PLoS ONE, 2017, Vol.7 (1)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0030073
原始语种摘要: Natural mutations in the LIPH gene were shown to be responsible for hair growth defects in humans and for the rex short hair phenotype in rabbits. In this species, we identified a single nucleotide deletion in LIPH (1362delA) introducing a stop codon in the C-terminal region of the protein. We investigated the expression of LIPH between normal coat and rex rabbits during critical fetal stages of hair follicle genesis, in adults and during hair follicle cycles. Transcripts were three times less expressed in both fetal and adult stages of the rex rabbits than in normal rabbits. In addition, the hair growth cycle phases affected the regulation of the transcription level in the normal and mutant phenotypes differently. LIPH mRNA and protein levels were higher in the outer root sheath (ORS)...
全文获取路径: DOAJ  (合作)
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影响因子:3.73 (2012)

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关键词翻译
关键词翻译
  • expression 表示
  • nucleotide 核苷酸
  • transfection 转染
  • normal 法线
  • mutant 突变体
  • region 地域
  • protein 蛋白质
  • times 
  • fetal 胎的
  • expressed 榨出的