Study on the Potential Toxicity of a Thymoquinone-Rich Fraction Nanoemulsion in Sprague Dawley Tats
作者: Maznah IsmailRozi MahmudMustapha Umar ImamZaki Tubesha
刊名: Molecules, 2013, Vol.18 (7), pp.7460-7472
来源数据库: Directory of Open Access Journals
DOI: 10.3390/molecules18077460
关键词: Sprague-Dawley ratsNanoemulsionThymoquinone rich fractionAcute oral toxicityHistopathologyHematology
原始语种摘要: Toxicological studies constitute an essential part of the effort in developing an herbal medicine into a drug product. A newly developed thymoquinone-rich fraction nanoemulsion (TQRFNE) has been prepared using a high pressure homogenizer. The purpose of this study was to investigate the potential acute toxicity of this nanoemulsion in Sprague Dawley rats. The acute toxicity studies were conducted as per the OECD guidelines 425, allowing for the use of test dose limit of 20 mL TQRFNE (containing 44.5 mg TQ)/kg. TQRFNE and distilled water (DW) as a control were administered orally to both sexes of rats on Day 0 and observed for 14 days. All the animals appeared normal, and healthy throughout the study. There was no observed mortality or any signs of toxicity during the experimental period....
全文获取路径: DOAJ  (合作)
影响因子:2.428 (2012)

  • toxicity 毒性
  • thymoquinone 百里香醌
  • unaffected 末触动的
  • histopathology 组织病理学
  • developing 显影
  • acute 急尖的
  • biochemistry 生化学
  • potential 
  • fraction 分数
  • administration 管理