Preparation and Characterization of Carbon Paste Electrode Bulk-Modified with Multiwalled Carbon Nanotubes and Its Application in a Sensitive Assay of Antihyperlipidemic Simvastatin in Biological Samples
作者: Amir M. AshrafiLukáš Richtera
刊名: Molecules, 2019, Vol.24 (12)
来源数据库: Directory of Open Access Journals
DOI: 10.3390/molecules24122215
关键词: Multiwalled carbon nanotubeCarbon paste electrodeScanning electrochemical microscopySimvastatin determinationMechanism studyBiological sample
原始语种摘要: Determination of an antihyperlipidemic drug simvastatin (SIM) was carried out using a carbon paste electrode bulk-modified with multiwalled carbon nanotubes (MWCNT-CPE). Scanning electrochemical microscopy (SECM), scanning electron microscopy (SEM), and atomic force microscopy (AFM) were used for the characterization of the prepared electrodes. Different electrodes were prepared varying in mass percentage of MWCNTs to find out the optimum amount of MWCNTs in the paste. The MWCNT-CPE in which the mass percentage of MWCNTs was 25% ( w/w ) was found as the optimum. Then, the prepared electrode was used in a mechanistic study and sensitive assay of SIM in pharmaceutical dosage form and a spiked human plasma sample using differential pulse voltammetry (DPV). The prepared electrode shows better...
全文获取路径: DOAJ  (合作)
影响因子:2.428 (2012)

  • spiked 有齿的
  • paste 膏剂
  • carbon 
  • determination 测定
  • pharmaceutical 
  • electrode 电极
  • plasma 深绿玉髓
  • microscopy 显微镜检查
  • dosage 放射剂量
  • multiwalled 多层的