Phase II/III Study of Radiofrequency Ablation Combined with Cytokine-Induced Killer Cells Treating Colorectal Liver Metastases
作者: Xiaodong LiXichao DaiLiangrong ShiYong JiangXuemin ChenLujun ChenJiemin ZhaoWeiguang QiangJun WuMei JiJingting JiangChangping Wu
刊名: Cellular Physiology and Biochemistry, 2016, Vol.40 (1-2), pp.137-145
来源数据库: Directory of Open Access Journals
DOI: 10.1159/000452531
关键词: Radiofrequency ablationCytokine-induced killer cellsProgression-free survivalOverall survivalColorectal liver metastases
原始语种摘要: Purpose: This phase II/III, non-randomized clinical trial aimed to determine the efficacy and safety of the combination of radiofrequency ablation (RFA) and cytokine-induced killer (CIK) cells transfusion for patients with colorectal liver metastases (CRLMs). Experimental Design: A total of 60 eligible patients with CRLMs were enrolled and divided into Group A (RFA alone, n = 30) and Group B (RFA plus CIK, n = 30), and following enzyme-linked immunosorbent spot assay was performed in 8 patients with CEA > 50 ng/mL pre-RFA and 7 days post-RFA and CIK treatment, respectively. Results: The median progression-free survival (PFS) times of Group A and Group B were 18.5 months and 23 months, respectively (P = 0.0336). The 3-year progression-free rates were 13.3% in Group A and 20.3% in Group B,...
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关键词翻译
关键词翻译
  • RFA Remote File Access
  • survival 生存
  • ablation 剥蚀
  • liver 
  • metastases 移位变化
  • cells 麻风细胞
  • killer 载劣扼杀剂
  • comparing 比较
  • induced 感应的
  • immunosorbent 免疫吸收剂