CONFIGURE: A pipeline for identifying context specific regulatory modules from gene expression data and its application to breast cancer
作者: Sungjoon ParkDoyeong HwangYoon Sun YeoHyunggee KimJaewoo Kang
刊名: BMC Medical Genomics, 2019, Vol.12 (S5), pp.1-8
来源数据库: Directory of Open Access Journals
DOI: 10.1186/s12920-019-0515-6
关键词: Context specific regulatory moduleGene regulatory network inferenceSingle sample GSEAFeature importance scoreBreast cancer subtype
原始语种摘要: Abstract Background Gene expression data is widely used for identifying subtypes of diseases such as cancer. Differentially expressed gene analysis and gene set enrichment analysis are widely used for identifying biological mechanisms at the gene level and gene set level, respectively. However, the results of differentially expressed gene analysis are difficult to interpret and gene set enrichment analysis does not consider the interactions among genes in a gene set. Results We present CONFIGURE, a pipeline that identifies context specific regulatory modules from gene expression data. First, CONFIGURE takes gene expression data and context label information as inputs and constructs regulatory modules. Then, CONFIGURE makes a regulatory module enrichment score (RMES) matrix of enrichment...
全文获取路径: DOAJ  (合作)
影响因子:3.466 (2012)

  • regulatory 控制的
  • breast 胸部
  • expression 表示
  • specific 
  • cancer 癌症
  • enrichment 富集
  • identifying 识别
  • constructs 建筑图纸生成系统
  • context 菌髓
  • score 得分