Insulin receptor isoform variations in prostate cancer cells
作者: Claire PerksJing WangCaroline JarrettMichael LadomeryAmit BahlAnthony RhodesJon OxleyJeff M P Holly
作者单位: 1University of Bristol
2University of the West of England
3Bristol Haematology and Oncology Centre
4University of Malaya
5North Bristol NHS Trust
刊名: Frontiers in Endocrinology, 2016, Vol.7
来源数据库: Directory of Open Access Journals
DOI: 10.3389/fendo.2016.00132
关键词: InsulinProstate cancerIGF-IIInsulin receptorSplice variants
原始语种摘要: Men who develop prostate cancer increasingly have one of the co-morbidities associated with a Western lifestyle that are characterised by hyperinsulinemia, hyperglycaemia and increased expression of insulin-like growth factors-I and –II. Each have been associated with poor prognosis and more aggressive cancers that exhibit increased metabolism and increased glucose uptake. The insulin receptor has two splice isoforms IR-A and IR-B: IR-A has a higher affinity for IGF-II comparable to that for insulin, whereas the IR-B isoform predominantly just binds to insulin. In this study we assessed alterations in the IR-A and IR-B isoform ratio and associated changes in cell proliferation and migration of prostate cancer cell lines following exposure to altered concentrations of glucose and treatment...
全文获取路径: DOAJ  (合作)

  • insulin 胰岛素
  • receptor 接受体
  • prostate 前列腺
  • hyperglycaemia 高8糖
  • cancer 癌症
  • glucose 葡萄糖
  • effective 有效的
  • carcinogenesis 癌形成
  • affinity 亲和力
  • altered 改变的