How reliable is Ki-67 immunohistochemistry in grade 2 breast carcinomas? A QA study of the Swiss Working Group of Breast- and Gynecopathologists.
作者: Zsuzsanna VargaJoachim DieboldCorina Dommann-ScherrerHarald FrickDaniela KaupAurelia NoskeEllen ObermannChristian OhlschlegelBarbara PadbergChristiane RakozySara Sancho OliverSylviane Schobinger-ClementHeide Schreiber-FacklamGad SingerCoya TapiaUrs WagnerMauro G MastropasquaGiuseppe VialeHans-Anton Lehr
刊名: PLoS ONE, 2017, Vol.7 (5)
来源数据库: Directory of Open Access Journals
DOI: 10.1371/journal.pone.0037379
原始语种摘要: UNLABELLED: Adjuvant chemotherapy decisions in breast cancer are increasingly based on the pathologist's assessment of tumor proliferation. The Swiss Working Group of Gyneco- and Breast Pathologists has surveyed inter- and intraobserver consistency of Ki-67-based proliferative fraction in breast carcinomas. METHODS: Five pathologists evaluated MIB-1-labeling index (LI) in ten breast carcinomas (G1, G2, G3) by counting and eyeballing. In the same way, 15 pathologists all over Switzerland then assessed MIB-1-LI on three G2 carcinomas, in self-selected or pre-defined areas of the tumors, comparing centrally immunostained slides with slides immunostained in the different laboratoires. To study intra-observer variability, the same tumors were re-examined 4 months later. RESULTS: The Kappa...
全文获取路径: DOAJ  (合作)
影响因子:3.73 (2012)

  • breast 胸部
  • grade 品位
  • Swiss 瑞士的
  • chemotherapy 化学疗法
  • pathologist 病理学家
  • observer 测候员
  • agreement 协议
  • slides 幻灯片
  • assessment 评价
  • inter