Phenotypical profile and global transcriptomic profile of Hypervirulent Klebsiella pneumoniae due to carbapenemase-encoding plasmid acquisition
作者: Dan LongLan-lan ZhuFang-ling DuTian-xin XiangLa-Gen WanDan-dan WeiWei ZhangYang Liu
刊名: BMC Genomics, 2019, Vol.20 (1), pp.1-13
来源数据库: Directory of Open Access Journals
DOI: 10.1186/s12864-019-5705-2
关键词: Hypervirulent K. pneumoniaeTranscriptomic analysisCarbapenemase plasmidRNA-Seq technique
原始语种摘要: Abstract Background Plasmids play an vital role in driving the rapid global spread of antimicrobial resistance and adaptation to changing ambient conditions. It has been suggested that the presence of plasmids can pose tremendous impacts on the host physiology. However, little is known regarding the contributions of carbapenemase-encoding plasmid carriage on the physiology and pathogenicity of hypervirulent K. pneumoniae (hvKP). Results Here we performed a transcriptomic analysis of hvKP with or without carbapenemase-encoding plasmid p24835-NDM5. The results had shown 683 genes with differential expression (false discovery rate, ≤0.001; > 2-fold change), of which 107 were up-regulated and 576 were down-regulated. Gene groups with functions relating to carbohydrate metabolism and multidrug...
全文获取路径: DOAJ  (合作)
影响因子:4.397 (2012)

  • plasmid 质粒
  • expression 表示
  • encoding 编码
  • biosynthesis 生物合成
  • increased 增加
  • strain 应变
  • global 球状的
  • antibiotic 抗生素
  • virulence 病毒性
  • capsule 胶囊