Two New Derivatives of 2, 5-Dihydroxyphenylacetic Acid from the Kernel of Entada phaseoloides
作者: Zhongmei ZouYing GuoMingyu BaYong ZhangGang DingLin Chen
刊名: Molecules, 2013, Vol.18 (2), pp.1477-1482
来源数据库: Directory of Open Access Journals
DOI: 10.3390/molecules18021477
关键词: Entada phaseoloidesLeguminosae25-dihydroxyphenylacetic acidHIV-1
原始语种摘要: Two new aromatic compounds, butyl 2,5-dihydroxyphenylacetate (1) and butyl 2-O-β-D-glucopyranosyloxy-5-dihydroxyphenylacetate (2), together with three known ones, methyl 2,5-dihydroxyphenylacetate (3), ethyl 2,5-dihydroxyphenylacetate (4) and 2-O-β-D-glucopyranosyloxy-5-hydroxyphenylacetic acid (5), were isolated from the EtOH extract of the kernel of Entada phaseoloides. The structures of the new compounds were elucidated by MS and NMR experiments. Compounds 1, 3 and 4 displayed potent inhibitory activities against HIV-1 replication, with EC50 values of 9.80 μM, 11.70 μM and 9.93 μM, respectively.
全文获取路径: DOAJ  (合作)
影响因子:2.428 (2012)

  • 丁基 共同
  • together 共同
  • butyl 共同
  • HIV Hydraulic Isolation Valve
  • kernel 
  • known 己知
  • values 价值观
  • against 反对
  • isolated 隔离
  • replication 复制
  • inhibitory 禁止的