Genome-Wide Association Study of MKI67 Expression and its Clinical Implications in HBV-Related Hepatocellular Carcinoma in Southern China
作者: Cheng-kun YangTing-dong YuChuang-ye HanWei QinXi-wen LiaoLong YuXiao-guang LiuGuang-zhi ZhuHao SuSi-cong LuZhi-wei ChenZhen LiuKe-tuan HuangZheng-tao LiuYu LiangJian-lu HuangZeng-nan MoXue QinLequn LiKai-yin XiaoMin-hao PengCheryl Ann WinkleStephen J. O'BrienTao Peng
刊名: Cellular Physiology and Biochemistry, 2017, Vol.42 (4), pp.1342-1357
来源数据库: Directory of Open Access Journals
DOI: 10.1159/000478963
关键词: HBV-related HCCMKI67GWASSouthern China
原始语种摘要: Background/Aims: Hepatocellular carcinoma (HCC) is a common malignant tumor with a high rate of recurrence. Immunohistochemical analysis of the marker of proliferation Ki-67 (MKI67) is used to assess proliferation activity of HCC The regulation of MKI67 expression remains unclear in HCC This study aims to explore the association between MKI67 expression and gene variants. Methods: A total of 195 hepatitis B virus (HBV)-related HCC patients were genotyped using Illumina HumanExome BeadChip-12-1_A (242,901 markers). An independent cohort (97 subjects) validated the association of polymorphism determinants and candidate genes with MKI67 expression. The relationships between MKI67 with p53 and variants of candidate genes in the clinical outcomes of HCC patients were analyzed. Results: We...
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  • expression 表示
  • related 有关的
  • China 中国
  • marker 标试器
  • association 联合
  • candidate 选择物
  • associated 相关的
  • recurrence 循环
  • potential 
  • polymorphism 多晶形