Fluconazole Ocular Inserts: Formulation and In -Vitro Evaluation
作者: Purna Chandra Rao. MNappinnai.MRaju.SUma Maheshwara Rao.VVenkateshwara Reddy. B
刊名: Journal of Pharmaceutical Sciences and Research, 2010, Vol.2 (11), pp.693
来源数据库: Directory of Open Access Journals
关键词: Fluconazole Ocular insertsSolvent casting techniqueZero order releaseIn Vitro Evaluation
原始语种摘要: The eye presents unique opportunities and challenges when it comes to the delivery of Pharmaceuticals. While absorption by this route is bungling, there are few side effects with conventional ocular dosage forms like eye drops and eye suspensions. Several polymeric systems have been used to fabricate ocular inserts for better ocular bioavailability and retention of drug for which gelling systems have shown advantages of convenient administration and increased contact time. Fluconazole ocular films were prepared using film forming polymers namely; Hydroxy propyl methyl cellulose, poly vinyl pyrrolidine and poly vinyl alcohol. PEG-400 was incorporated as plasticizer. Solvent casting technique was followed to prepare fluconazole ocular inserts. Seven formulations were formulated .The...
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关键词翻译
关键词翻译
  • polymeric 聚合的
  • prepare 准备
  • retention 保留
  • forming 成形
  • incorporated 股份有限公司
  • convenient 方便的
  • drops 沉积岩侵入漏斗状体
  • ocular 目镜
  • excised 切断的
  • films 薄膜