Dopaminergic profile of new heterocyclic N-phenylpiperazine derivatives
作者: Neves G.Fenner R.Heckler A.P.Viana A.F.Tasso L.Menegatti R.Fraga C.A.M.Barreiro E.J.Dalla-Costa T.Rates S.M.K.
刊名: Brazilian Journal of Medical and Biological Research, 2003, Vol.36 (5), pp.625
来源数据库: Directory of Open Access Journals
关键词: N-phenylpiperazine derivativesDopamineApomorphine hypothermiaAmphetamine stereotypyCatalepsy
原始语种摘要: Dopamine constitutes about 80% of the content of central catecholamines and has a crucial role in the etiology of several neuropsychiatric disorders, including Parkinson's disease, depression and schizophrenia. Several dopaminergic drugs are used to treat these pathologies, but many problems are attributed to these therapies. Within this context, the search for new more efficient dopaminergic agents with less adverse effects represents a vast research field. The aim of the present study was to report the structural design of two N-phenylpiperazine derivatives, compound 4: 1-[1-(4-chlorophenyl)-1H-4-pyrazolylmethyl]-4-phenylhexahydropyrazine and compound 5: 1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-ylmethyl]-4-phenylhexahydropyrazine, planned to be dopamine ligands, and their dopaminergic...
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  • dopaminergic 多巴胺能的多巴胺能的
  • apomorphine 阿朴吗啡
  • stereotypy 刻板动作刻板症
  • profile 纵断图
  • haloperidol 氟呱啶醇
  • schizophrenia 精神分裂症
  • catalepsy 僵住症
  • derivatives 派生物
  • induced 感应的
  • heterocyclic 杂环的