Association Between Genetic Polymorphisms of the β1-Adrenergic Receptor and Sensitivity to Pain and Fentanyl in Patients Undergoing Painful Cosmetic Surgery
作者: Ayako MoriyamaDaisuke NishizawaShinya KasaiJunko HasegawaKen-ichi FukudaMakoto NagashimaRyoji KatohKazutaka Ikeda
作者单位: 1ddictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamimitazawa, Setagaya-ku, Tokyo 156-8506, Japan; Department of Surgery, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura-shi, Chiba 285-8741, Japan
2Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamimitazawa, Setagaya-ku, Tokyo 156-8506, Japan
3Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamimitazawa, Setagaya-ku, Tokyo 156-8506, Jap
刊名: Journal of Pharmacological Sciences, 2019, Vol.121 (1), pp.48-57
来源数据库: Directory of Open Access Journals
原始语种摘要: Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. The adrenergic system is reportedly involved in the mechanisms of pain and analgesia. Here, we focused on one of the adrenergic receptor genes, ADRB1, and analyzed the influence of single-nucleotide polymorphisms (SNPs) in the ADRB1 gene on individual differences in pain and analgesic sensitivity. We examined associations between pain and fentanyl sensitivity and the two SNPs, A145G and G1165C, in the human ADRB1 gene in 216 Japanese patients who underwent painful orofacial cosmetic surgery, including bone dissection. The patients who carried the A-allele of the A145G SNP were more sensitive to cold pressor–induced pain than those who did not carry this allele,...
全文获取路径: DOAJ  (合作)
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来源刊物:
影响因子:2.15 (2012)

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关键词翻译
关键词翻译
  • analgesic 镇痛药
  • fentanyl 芬太尼
  • opioid 鸦片样物质
  • analgesia 痛觉缺失
  • postoperative 手术后的
  • Association 美国公共卫生协会
  • painful 痛苦的
  • sensitivity 灵敏度
  • haplotype 单倍体型
  • allele 等位基因