Angiotropism and extravascular migratory metastasis in cutaneous and uveal melanoma progression in a zebrafish model
作者: Giulia FornabaioRaymond L. BarnhillClaire LugassyLaurent A. BentolilaNathalie CassouxSergio Roman-RomanSamar AlsafadiFilippo Del Bene
刊名: Scientific Reports, 2018, Vol.8 (1), pp.1-12
来源数据库: Directory of Open Access Journals
DOI: 10.1038/s41598-018-28515-6
原始语种摘要: Abstract Cutaneous melanoma is a highly aggressive cancer with a propensity for distant metastasis to various organs. In contrast, melanoma arising in pigmented uveal layers of the eye metastasizes mostly in the liver. The mechanisms of these metastases, which are ultimately resistant to therapy, are still unclear. Metastasis via intravascular dissemination of tumour cells is widely accepted as a central paradigm. However, we have previously described an alternative mode of tumour dissemination, extravascular migratory metastasis, based on clinical and experimental data. This mechanism is characterised by the interaction of cancer cells with the abluminal vascular surface, which defines angiotropism. Here, we employed our 3D co-culture approach to monitor cutaneous and uveal human...
全文获取路径: DOAJ  (合作)
影响因子:2.927 (2012)

  • melanoma 黑瘤
  • metastasis 同质蜕变
  • extravascular 血液外的
  • migratory 迁移的
  • cutaneous 皮肤的
  • tumour 肿瘤
  • cells 麻风细胞
  • distant 远离的
  • progression 级数
  • liver