Practical considerations for estimating clinical trial accrual periods: application to a multi-center effectiveness study
作者: Carter Rickey Sonne Susan Brady Kathleen
刊名: BMC Medical Research Methodology, 2005, Vol.5 (1), pp.11
来源数据库: Directory of Open Access Journals
原始语种摘要: Abstract Background Adequate participant recruitment is vital to the conduct of a clinical trial. Projected recruitment rates are often over-estimated, and the time to recruit the target population (accrual period) is often under-estimated. Methods This report illustrates three approaches to estimating the accrual period and applies the methods to a multi-center, randomized, placebo controlled trial undergoing development. Results Incorporating known sources of accrual variation can yield a more justified estimate of the accrual period. Simulation studies can be incorporated into a clinical trial's planning phase to provide estimates for key accrual summaries including the mean and standard deviation of the accrual period. Conclusion The accrual period of a clinical trial should be...
全文获取路径: DOAJ  (合作)
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影响因子:2.211 (2012)

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关键词翻译
关键词翻译
  • accrual 应计
  • estimating 价值估计
  • estimate 估计
  • center 中心
  • trial 试验
  • often 往往
  • participant 参与者
  • justified 两端
  • allocation 分配
  • deviation 偏差