Protein secretion in human mammary epithelial cells following HER1 receptor activation: influence of HER2 and HER3 expression
作者: Zhang YiGonzalez Rachel Zangar Richard
刊名: BMC Cancer, 2011, Vol.11 (1), pp.69
来源数据库: Directory of Open Access Journals
原始语种摘要: Abstract Background Protein secretion by mammary cells results in autocrine and paracrine signaling that defines cell growth, migration and the extracellular environment. Even so, we have a limited understanding of the cellular processes that regulate protein secretion. Methods In this study, we utilize human epithelial mammary cell (HMEC) lines that were engineered to express different levels of HER1, HER2 and HER3. Using an ELISA microarray platform, we evaluate the effects of epidermal growth factor family receptor (HER) expression on protein secretion in the HMEC lines upon initiation of HER1 receptor activation. The secreted proteins include three HER1 ligands, interleukins 1α and 18, RANTES, vascular-endothelial and platelet-derived growth factors, matrix metalloproteases 1, 2 and...
全文获取路径: DOAJ  (合作)
影响因子:3.333 (2012)

  • secretion 分泌
  • receptor 接受体
  • mammary 乳房的
  • activation 活化
  • expression 表示
  • epithelial 上皮的
  • protein 蛋白质
  • human 人的
  • altering 修改
  • signaling 发信号