Inhibition of Inflammatory Mediators by Neobavaisoflavone in Activated RAW264.7 Macrophages
作者: Ewelina SzliszkaDariusz SkabaZenon P. CzubaWojciech Krol
刊名: Molecules, 2011, Vol.16 (5), pp.3701
来源数据库: Directory of Open Access Journals
关键词: neobavaisoflavoneanti-inflammatory activityRAW264.7 macrophages
原始语种摘要: Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and...
全文获取路径: DOAJ  (合作)
影响因子:2.428 (2012)

  • macrophages 巨噬细胞
  • inflammatory 激怒的
  • antibacterial 抗细菌的
  • stimulated 受激
  • flavonoids 黄酮类似物
  • responsible 负责的
  • cytokines 细胞浆移动
  • bioactive 对活质起作用的
  • inflammation 炎症
  • release 释放