Cytotoxicity and Oral Acute Toxicity Studies of Lantana camara Leaf Extract
作者: Badakhshan Mahdi PourLachimanan Yoga LathaSreenivasan Sasidharan
刊名: Molecules, 2011, Vol.16 (5), pp.3663
来源数据库: Directory of Open Access Journals
关键词: Lantana camaracytotoxicityoral acute toxicityVero cellplant extract
原始语种摘要: Background: The objective of this study was to investigate the toxicity of Lantana camara methanol extract. Methods: In order to evaluate the toxicity of Lantana camara, the acute toxicity of the methanolic extract on adult mice and cytotoxicity test on Vero cell line were investigated. A fixed large dose of 2 g/kg body weight of L. camara leaf extract was administrated by a single oral gavage according to the OECD procedure. Results: In 2 weeks, L. camara leaf extract showed no obvious acute toxicity. While female mice lost body weight after being treated with single dose of leaf extract in acute toxicity test, male ones lost organ mass, particularly for heart and kidney. The biochemical liver function tests showed significantly elevated TBIL and ALT in the L. camara leaf extract treated...
全文获取路径: DOAJ  (合作)
影响因子:2.428 (2012)

  • 浓聚物 按照
  • camara 果室
  • toxicity 毒性
  • extract 提取
  • investigate 
  • female 女性的
  • gavage 管饲法
  • according 按照
  • concentrations 按照
  • liver 
  • confirm 确认