Site specific increase in heterogeneity of trabecular bone tissue mineral during oestrogen deficiency
作者: MA BrennanJP GleesonM BrowneFJ O'BrienPJ ThurnerLM McNamara
刊名: European Cells and Materials (ECM), 2011, Vol.21 , pp.396
来源数据库: Directory of Open Access Journals
关键词: Bonemineralheterogeneityosteoporosisoestrogen deficiencybackscattered electron imaging
原始语种摘要: Although osteoporosis reduces overall bone mass causing bone fragility, recent studies report that the remaining bone tissue is significantly stiffer. Preliminary studies indicate that alterations in bone tissue mineral content might explain these changes, albeit that other studies report conflicting observations. The objective of this study is to quantify whether the distribution of bone tissue mineral is altered during oestrogen deficiency. Individual trabeculae were harvested from the proximal femur of 7 ovariectomised sheep (OVX), sacrificed 12 months post-surgery, and 5 age-matched controls. Mineral content (wt% Ca) was determined using a quantitative backscattered scanning electron microscopy imaging approach. Mineral heterogeneity within individual trabeculae was compared by...
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影响因子:4.558 (2012)

  • oestrogen 雌激素
  • trabecular 小梁的
  • heterogeneity 不均匀性
  • mineral 矿物
  • tissue 组织
  • proximal 接近的
  • trabeculae 横条
  • femur 股骨
  • increase 增加
  • lesser 稍小的