Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms
作者: AMC BarradasH YuanCA van BlitterswijkP Habibovic
刊名: European Cells and Materials (ECM), 2011, Vol.21 , pp.407
来源数据库: Directory of Open Access Journals
关键词: Osteoinductionbiomaterialsceramicscalcium phosphatesbone regeneration
原始语种摘要: In the past thirty years, a number of biomaterials have shown the ability to induce bone formation when implanted at heterotopic sites, an ability known as osteoinduction. Such biomaterials – osteoinductive biomaterials – hold great potential for the development of new therapies in bone regeneration. Although a variety of well characterised osteoinductive biomaterials have so far been reported in the literature, scientists still lack fundamental understanding of the biological mechanism underlying the phenomenon by which they induce bone formation. This is further complicated by the observations that larger animal models are required for research, since limited, if any, bone induction by biomaterials is observed in smaller animals, including particularly rodents. Besides interspecies...
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影响因子:4.558 (2012)

  • biological 生物学的
  • properties 道具
  • knowledge 知识
  • chemical 化学的
  • conditions 条件式
  • these 这些的
  • species 
  • occur 产生
  • fundamental 基本的
  • observed 观察到的