Acute Oral Toxicity and Brine Shrimp Lethality of Elaeis guineensis Jacq., (Oil Palm Leaf) Methanol Extract
作者: Abdul Rani Muhamad SyahmiSoundararajan VijayarathnaSreenivasan SasidharanLachimanan Yoga LathaYuet Ping KwanYee Ling LauLai Ngit ShinYeng Chen
刊名: Molecules, 2010, Vol.15 (11), pp.8111
来源数据库: Directory of Open Access Journals
关键词: Elaeis guineensismethanol extractacute oral toxicitybrine shrimp lethality assay
原始语种摘要: Elaeis guineensis (Arecaceae) is widely used in West African traditional medicine for treating various ailments. An evaluation on the toxicity of extracts of this plant is crucial to support the therapeutic claims. The acute oral toxicity and brine shrimp lethality of a methanolic extract of this plant was tested. Oral administration of crude extract at the highest dose of 5,000 mg/kg resulted in no mortalities or evidence of adverse effects, implying that E. guineensis is nontoxic. Normal behavioral pattern, clinical signs and histology of vital organs confirm this evidence. The E. guineensis extracts screened for toxicity against brine shrimp had 50% lethal concentration (LC50) values of more than 1.0 mg/mL (9.00 and 3.87 mg/mL, at 6 and 24 h, respectively), confirming that the extract...
全文获取路径: DOAJ  (合作)
影响因子:2.428 (2012)

  • concentration 浓度
  • nontoxic 无毒的
  • lethality 死亡率
  • organs 男生殖器
  • extracts 摘记
  • toxicity 毒性
  • shrimp 小虾
  • screened 筛过的
  • administration 管理
  • widely 广泛地