Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice
作者: Nan YueMinWang RongQiZhao SuXianHan FangWu WenKong LingBoFu NaKong LiYu Jun
刊名: Lipids in Health and Disease, 2010, Vol.9 (1), pp.124
来源数据库: Directory of Open Access Journals
原始语种摘要: Abstract Objective Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, has been reported to have potential antioxidant properties. However, the role of HO-1 on hepatocyte apoptosis remains unclear. We aim to elucidate the effects of HO-1 on oxidative stress related hepatocellular apoptosis in nutritional steatohepatitis in mice. Methods C57BL/6J mice were fed with methionine-choline deficient (MCD) diet for four weeks to induce hepatic steatohepatitis. HO-1 chemical inducer (hemin), HO-1 chemical inhibitor zinc protoporphyrin IX (ZnPP-IX) and/or adenovirus carrying HO-1 gene (Ad-HO-1) were administered to mice, respectively. Hepatocyte apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay, the mRNA and protein expression of...
全文获取路径: DOAJ  (合作)
影响因子:2.015 (2012)

  • hepatocyte 肝细胞
  • suppressing 制止的
  • apoptosis 细胞死
  • alcoholic 醇的
  • oxygenase 氧合酶
  • hepatic 肝的
  • hepatocellular 肝细胞性的
  • regulated 规定
  • hemin 血晶质
  • cytochrome 细胞色素