db-Cyclic adenosine monophosphate promotes axon regeneration and motor function recovery in cerebral ischemia-reperfusion rats
| 作者： | Niu Lingchuan, Zhou Jia, Huang Ying, Chen Yan, Li Changqing |
| 刊名： | Neurology India, 2010, Vol.58 (2), pp.195 |
| 来源数据库： | Directory of Open Access Journals |
| 关键词： | Axon regeneration; cerebral ischemia; dual-acid cyclic adenosine monophosphate; growth associated Protein-43; RhoA.; |
| 原始语种摘要： | Background: There is no effective axon regeneration in adult mammalians. Objective: To investigate the effects of dual-acid cyclic adenosine monophosphate (db-cAMP) on the axon regeneration, motor function recovery and RhoA signal pathway in cerebral ischemia-reperfusion rats, and to explore the possible clinical application and mechanism. Materials and Methods: Middle cerebral artery ischemia-reperfusion model was established by nylon monofilament occlusion method in 105 Sprague-Dawley (SD) rats. Semi-quantitative Western blot analysis was used to assess protein expression level of growth-associated protein-43 (GAP-43) and RhoA. Montoya staircase test score was used to test the motor function of affected forelimb. Results: Compared to the ischemia group, the staircase test score in the... |
