In Vitro Antioxidant Activity and Hepatoprotective Effects of Lentinula edodes against Paracetamol-Induced Hepatotoxicity
作者: Sreenivasan SasidharanSugumaran AravindranLachimanan Yoga LathaRatnasamy VijenthiDharmaraj SaravananSanthanam Amutha
刊名: Molecules, 2010, Vol.15 (6), pp.4478
来源数据库: Directory of Open Access Journals
关键词: Lentinula edodeshepatoprotective activityantioxidant activityliver marker enzymes
原始语种摘要: Background: The objective of this study was to investigate the antioxidant and hepatoprotective effects of methanolic extracts of L. edodes and the determination of their total phenolics content. Results: The amount of total phenolics was estimated to be 70.83 mg Gallic Acid Equivalent (GAE) per gram of dry extract. The antioxidant activity of the L. edodes extract was 39.0% at a concentration of 1 mg/mL and was also concentration dependant, with an EC50 value of 4.4 mg/mL. Different groups of animals (Wister albino mice) were administered paracetamol (1 g/kg, p.o.). L. edodes extract at a dose of 200 mg/kg was administered to the paracetamol treated mice for seven days. The effects of L. edodes extract on serum transaminases (SGOT, SGPT), alkaline phosphatase (ALP) and bilirubin were...
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影响因子:2.428 (2012)

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关键词翻译
关键词翻译
  • paracetamol 4乙酰氨基酚
  • against 反对
  • extract 提取
  • bilirubin 胆红素
  • induced 感应的
  • albino 白化体
  • hepatotoxic 肝毒性的
  • antioxidant 抗氧化剂
  • determination 测定
  • liver