Simultaneous RP-HPLC and HPTLC estimation of fluoxetine hydrochloride and olanzapine in tablet dosage forms
作者: Patel SejalPatel N
刊名: Indian Journal of Pharmaceutical Sciences, 2009, Vol.71 (4), pp.477
来源数据库: Directory of Open Access Journals
关键词: Fluoxetine HClolanzapineRP-HPLCHPTLCsimultaneous estimation
原始语种摘要: A binary mixture of fluoxetine HCl and olanzapine was determined by two different methods. The first method involved determination of fluoxetine HCl and olanzapine using reversed-phase liquid chromatography using acetonitrile:methanol:0.032 M ammonium acetate buffer (45:05:50, v/v/v) as the mobile phase at a flow rate of 1.5 ml/min. Quantitation was achieved with ultraviolet detection at 235 nm over concentration ranges of 0.2-4 and 0.1-2 μg/ml; mean accuracies were 101.16±0.59 and 99.79±0.56% for fluoxetine HCL and olanzapine, respectively. The second method was based on the high performance thin layer chromatography separation of the two drugs followed by densitometric measurements of their spots at 235 nm. The separation was carried out on Merck TLC aluminium sheets of silica gel 60...
全文获取路径: DOAJ  (合作)
影响因子:0.338 (2012)

  • fluoxetine 氟西汀
  • hydrochloride 盐酸盐
  • tablet 药片
  • acetate 醋酸盐
  • determination 测定
  • reversed 倒转的
  • dosage 放射剂量
  • acetonitrile 乙腈
  • methanol 甲醇
  • mobile 可动的