Early manifestation of alteration in cardiac function in dystrophin deficient mdx mouse using 3D CMR tagging
作者: Li WeiLiu WeiZhong JiaYu Xin
刊名: Journal of Cardiovascular Magnetic Resonance, 2009, Vol.11 (1), pp.40
来源数据库: Directory of Open Access Journals
原始语种摘要: Abstract Background Duchenne muscular dystrophy (DMD) is caused by the absence of the cytoskeletal protein, dystrophin. In DMD patients, dilated cardiomyopathy leading to heart failure may occur during adolescence. However, early cardiac dysfunction is frequently undetected due to physical inactivity and generalized debilitation. The objective of this study is to determine the time course of cardiac functional alterations in mdx mouse, a mouse model of DMD, by evaluating regional ventricular function with CMR tagging. Methods In vivo myocardial function was evaluated by 3D CMR tagging in mdx mice at early (2 months), middle (7 months) and late (10 months) stages of disease development. Global cardiac function, regional myocardial wall strains, and ventricular torsion were quantified....
全文获取路径: DOAJ  (合作)
影响因子:4.435 (2012)

  • tagging 锻尖
  • dystrophin 抗肌萎缩蛋白
  • function 函数
  • torsion 扭转
  • mouse 小鼠
  • regional 地方的
  • myocardial 心肌的
  • determine 决心
  • early 
  • cardiac 贲门