3-O-Methylfunicone, a Selective Inhibitor of Mammalian Y-Family DNA Polymerases from an Australian Sea Salt Fungal Strain
作者: Yoshiyuki MizushinaHirohisa MotoshimaYasuhiro YamaguchiToshifumi TakeuchiKen HiranoFumio SugawaraHiromi Yoshida
刊名: Marine Drugs, 2009, Vol.7 (4), pp.624
来源数据库: Directory of Open Access Journals
关键词: 3-O-methylfuniconeY-family DNA polymeraseDNA polymerase κenzyme inhibitormarine fungal strainsAustralian sea saltanti-cancer drug
原始语种摘要: We isolated a pol inhibitor from the cultured mycelia extract of a fungal strain isolated from natural salt from a sea salt pan in Australia, which was identified as 3-O-methylfunicone by spectroscopic analyses. This compound selectively inhibited the activities of mammalian Y-family DNA polymerases (pols) (i.e., pols η, ι and κ). Among these pols, human pol κ activity was most strongly inhibited, with an IC50 value of 12.5 μM. On the other hand, the compound barely influenced the activities of the other families of mammalian pols, such as A-family (i.e., pol γ), B-family (i.e., pols α, δ and ε) or X-family (i.e., pols β, λ and terminal deoxynucleotidyl transferase), and showed no effect on the activities of fish pol δ, plant pols, prokaryotic pols and other DNA metabolic enzymes, such as...
全文获取路径: DOAJ  (合作)
影响因子:3.978 (2012)

  • prokaryotic 原核生物的
  • transcriptase 转录酶
  • family 
  • DNA Deoxyribonucleic Acid
  • mammalian 哺乳动物
  • inhibitor 抑制剂
  • human 人的
  • primase 引发酶
  • isolated 隔离
  • lower 降下