Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma
作者: Torng Pao-LingLin Ching-WeiChan Michael Yang Hui-WenHuang Su-ChengLin Chin-Tarng
刊名: Molecular Cancer, 2009, Vol.8 (1), pp.120
来源数据库: Directory of Open Access Journals
原始语种摘要: Abstract Background Insulin-like growth factor binding protein (IGFBP-3) is an antiproliferative, pro-apoptotic and invasion suppressor protein which is transcriptionally regulated by p53. Promoter methylation has been linked to gene silencing and cancer progression. We studied the correlation between IGFBP-3 and p53 expression as well as IGFBP-3 promoter methylation in ovarian endometrioid carcinoma (OEC) by immunohistochemical staining and quantitative methylation-specific PCR (qMSP). Additionally, we assessed the molecular regulatory mechanism of wild type (wt) p53 on IGFBP-3 expression using two subclones of OEC, the OVTW59-P0 (low invasive) and P4 (high invasive) sublines. Results In 60 cases of OEC, 40.0% showed lower IGFBP-3 expression which was significantly correlated with higher...
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影响因子:5.134 (2012)

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关键词翻译
关键词翻译
  • 突变形成 Orientation Execution Code
  • expression 表示
  • methylation 甲基化酌
  • endometrioid 子宫内膜样的
  • promoter 催化剂
  • ovarian 卵巢的
  • lower 降下
  • OEC Orientation Execution Code
  • mutagenesis Orientation Execution Code
  • carcinoma 癌症
  • upstream 向上游