Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones
作者: Heloise BriceJonathan ClaydenStuart D. Hamilton
刊名: Beilstein Journal of Organic Chemistry, 2010, Vol.6 (1), pp.22
来源数据库: Directory of Open Access Journals
关键词: bicycliccyclisationdearomatisationenol etherheterocyclepyridinequinoline
原始语种摘要: The silyl enol ether derivatives of ketones or esters tethered by a hydrocarbon or ether linkage to the 3-position of a pyridine ring undergo dearomatising nucleophilic attack on the ring once it is activated (as an acylpyridinium species) by the addition of methyl chloroformate. The bicyclic dihydropyridine products are in some cases unstable, but may be isolated after hydrogenation as fused bicyclic piperidines.
全文获取路径: DOAJ  (合作)
影响因子:2.801 (2012)

  • esters 酯类
  • bicyclic 二环的
  • substituted 取代的
  • nucleophilic 亲核的
  • ether 以太
  • pyridine 吡啶
  • hydrogenation 加氢
  • chloroformate 氯甲酸盐
  • silyl 甲硅烷基
  • derivatives 派生物