A highly invasive human glioblastoma pre-clinical model for testing therapeutics
作者: Xie QianThompson RyanHardy KimDeCamp LisaBerghuis BreeSigler RobertKnudsen BeatriceCottingham SandraZhao PingDykema KarlCao BrianResau JamesHay RickVande Woude George
刊名: Journal of Translational Medicine, 2008, Vol.6 (1), pp.77
来源数据库: Directory of Open Access Journals
原始语种摘要: Abstract Animal models greatly facilitate understanding of cancer and importantly, serve pre-clinically for evaluating potential anti-cancer therapies. We developed an invasive orthotopic human glioblastoma multiforme (GBM) mouse model that enables real-time tumor ultrasound imaging and pre-clinical evaluation of anti-neoplastic drugs such as 17-(allylamino)-17-demethoxy geldanamycin (17AAG). Clinically, GBM metastasis rarely happen, but unexpectedly most human GBM tumor cell lines intrinsically possess metastatic potential. We used an experimental lung metastasis assay (ELM) to enrich for metastatic cells and three of four commonly used GBM lines were highly metastatic after repeated ELM selection (M2). These GBM-M2 lines grew more aggressively orthotopically and all showed dramatic...
全文获取路径: DOAJ  (合作)
影响因子:3.459 (2012)

  • glioblastoma 成胶质细胞瘤
  • intracranial 颅内的
  • invasive 侵入的
  • orthotopic 常位的
  • antitumor 抗癌的
  • therapeutics 治疗学
  • human 人的
  • geldanamycin 格尔德霉素
  • potential 
  • metastatic 新陈代谢的