Peroxisome Proliferator-Activated Receptors in HCV-Related Infection
作者: Sébastien DharancyMaud LemoinePhilippe MathurinLawrence SerfatyLaurent Dubuquoy
刊名: PPAR Research, 2009, Vol.2009
来源数据库: Directory of Open Access Journals
原始语种摘要: The topic of peroxisome proliferator-activated receptors has been developed in the field of hepatology allowing envisaging therapeutic strategies for the most frequent chronic liver diseases such as chronic infection with hepatitis C virus (HCV). PPARs contribute to wide physiological processes within the liver such as lipid/glucid metabolisms, inflammatory response, cell differentiation, and cell cycle. In vitro experiments and animal studies showed that PPARα discloses anti-inflammatory property, and PPARγ discloses anti-inflammatory, antifibrogenic, and antiproliferative properties in the liver. Experimental and human studies showed impaired PPARs expression and function during HCV infection. The available nonhepatotoxic agonists of PPARs may constitute a progress in the therapeutic...
全文获取路径: DOAJ  (合作)
影响因子:2.685 (2012)

  • chronically 长期地
  • inflammatory 激怒的
  • liver 
  • peroxisome 过氧化物酶体
  • therapeutic 治疗的
  • contribute 贡献
  • hepatitis 肝炎
  • infection 感染
  • hepatology 肝脏病学
  • lipid 脂质