Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms
作者: Prasad PushplataTiwari Arun Kumar KM PrasannaAmmini ACGupta ArvindGupta RajeevSharma AKRao ARNagendra RChandra T SatishTiwari SCRastogi PriyankaGupta B LalThelma BK
刊名: BMC Medical Genetics, 2006, Vol.7 (1), pp.42
来源数据库: Directory of Open Access Journals
原始语种摘要: Abstract Background Renal failure in diabetes is mediated by multiple pathways. Experimental and clinical evidences suggest that renin-angiotensin-aldosterone system (RAAS) has a crucial role in diabetic kidney disease. A relationship between the RAAS genotypes and chronic renal insufficiency (CRI) among type 2 diabetes subjects has therefore been speculated. We investigated the contribution of selected RAAS gene polymorphisms to CRI among type 2 diabetic Asian Indian subjects. Methods Twelve single nucleotide polymorphisms (SNPs) from six genes namely-renin (REN), angiotensinogen (ATG), angiotensin converting enzyme I (ACE), angiotensin II type 1 receptor (AT1) and aldosterone synthase (CYP11B2) gene from the RAAS pathway and one from chymase pathway were genotyped using polymerase chain...
全文获取路径: DOAJ  (合作)
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影响因子:2.536 (2012)

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关键词翻译
关键词翻译
  • RAAS 肾素-血管紧张素-醛固酮系统
  • diabetes 糖尿病
  • insufficiency 机能不全
  • renal 肾的
  • chymase 凝乳酶
  • angiotensin 血管紧张肽
  • aldosterone 醛甾酮
  • diabetic 糖尿病患者
  • converting 转换
  • renin 肾活素