Association of TGFβ1, TNFα, CCR2 and CCR5 gene polymorphisms in type-2 diabetes and renal insufficiency among Asian Indians
作者: Prasad PushplataTiwari Arun Kumar KM PrasannaAmmini ACGupta ArvindGupta RajeevThelma BK
刊名: BMC Medical Genetics, 2007, Vol.8 (1), pp.20
来源数据库: Directory of Open Access Journals
原始语种摘要: Abstract Background Cytokines play an important role in the development of diabetic chronic renal insufficiency (CRI). Transforming growth factor β1 (TGF β1) induces renal hypertrophy and fibrosis, and cytokines like tumor necrosis factor-alpha (TNFα), chemoattractant protein-1 (MCP-1), and regulated upon activation and normal T cell expressed and secreted (RANTES) mediate macrophage infiltration into kidney. Over expression of these chemokines leads to glomerulosclerosis and interstitial fibrosis. The effect of MCP-1 and RANTES on kidney is conferred by their receptors i.e., chemokine receptor (CCR)-2 and CCR-5 respectively. We tested association of nine single nucleotide polymorphisms (SNPs) from TGFβ1, TNFα, CCR2 and CCR5 genes among individuals with type-2 diabetes with and without...
全文获取路径: DOAJ  (合作)
影响因子:2.536 (2012)

  • 间隙原子 视网膜病
  • insufficiency 机能不全
  • TNF Transfer on No Overflow
  • renal 肾的
  • CCR Carriage Control Register
  • diabetes 糖尿病
  • diabetic 糖尿病患者
  • retinopathy 视网膜病
  • interstitial 视网膜病
  • predisposition 素质
  • protein 蛋白质