Severe phenytoin toxicity in a CYP2C9FNx013FNx013 homozygous mutant from India
作者: Ramasamy KesavanNarayan Sunil Chanolean ShashindranChandrasekaran Adithan
刊名: Neurology India, 2007, Vol.55 (4), pp.408
来源数据库: Directory of Open Access Journals
关键词: CYP2C9 polymorphismphenytoin toxicity
原始语种摘要: The authors report an Indian adult female patient with a history of generalized tonic clonic seizures who developed severe features of phenytoin (DPH) toxicity on therapeutic dosage of this antiepileptic drug. Administration of 300mg/day of DPH in this patient resulted in toxic symptoms associated with an excessive serum DPH concentration of 33μg/ml. The PCR-RFLP analysis revealed a homozygosity involving CYP2C9FNx013FNx013. This mutation results in a marked decrease in the enzymatic activity (CYP2C9) and leads to a decreased clearance of the drug which can lead to severe acute and chronic toxicity. On switching the antiepileptic therapy from DPH to sodium valproate, there was reversal of both.
全文获取路径: DOAJ  (合作)
影响因子:1.044 (2012)

  • phenytoin 苯妥英
  • antiepileptic 镇痫剂
  • toxicity 毒性
  • clonic 无性系的
  • homozygosity 纯合性
  • excessive 过度
  • homozygous 纯合的
  • adult 成体
  • female 女性的
  • therapeutic 治疗的