Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes
作者: Prasad PushplataKumar KM PrasannaAmmini ACGupta ArvindGupta RajeevThelma BK
刊名: BMC Genetics, 2008, Vol.9 (1), pp.26
来源数据库: Directory of Open Access Journals
原始语种摘要: Abstract Background Genetic markers conferring susceptibility to diabetes specific renal disease remains to be identified for early prediction and development of effective drugs and therapies. Inconsistent results obtained from analysis of genes from classical pathways generate need for examination of unconventional genetic markers having role in regulation of renal function. Experimental and clinical evidences suggest that dopamine is an important natriuretic hormone. Therefore, various genes involved in regulation of dopamine bioavailability could play a role in diabetic chronic renal insufficiency (CRI). We investigated the contribution of 12 polymorphisms from five Dopaminergic pathway genes to CRI among type-2 diabetic Asian Indian subjects. Methods Genetic association of 12...
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影响因子:2.808 (2012)

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关键词翻译
关键词翻译
  • among 在当中
  • renal 肾的
  • dopamine 多巴胺
  • insufficiency 机能不全
  • diabetes 糖尿病
  • association 联合
  • upstream 向上游
  • confirmed 已确认的
  • genetic 遗传的
  • pathway 轨道