Folate-modified lipid–polymer hybrid nanoparticles for targeted paclitaxel delivery
作者: Dunwan ZhuCunxian SongHongfan SunXia DongDeling KongLinhua ZhangChun Wang
作者单位: 1Chinese Academy of Medical Sciences & Peking Union Medical College
2The Institute of Biomedical Engineering
3Nankai University
4Institute of Biomedical Engineering, Peking U
刊名: International Journal of Nanomedicine, 2015, Vol.2015 (default), pp.2101-2114
来源数据库: Dove Journal
DOI: 10.2147/IJN.S77667
原始语种摘要: The purpose of this study was to develop a novel lipid-polymer hybrid drug carrier comprised of folate (FA) modified lipid-shell and polymer-core nanoparticles (FLPNPs) for sustained, controlled and targeted delivery of paclitaxel (PTX). The core-shell NPs consist of (i) a poly(ɛ-caprolactone) hydrophobic core based on self-assembly of poly(ɛ-caprolactone)-poly(ethylene glycol)-poly(ɛ-caprolactone) (PCL-PEG-PCL) amphiphilic copolymers, (ii) a lipid monolayer formed with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol) -2000] (DSPE-PEG2000), (iii) a targeting ligand (FA) on the surface, and were prepared using a thin-film hydration and ultrasonic dispersion method. Transmission electron microscopy and dynamic light scattering analysis confirmed the coating...
全文获取路径: Dove 
影响因子:3.463 (2012)

  • monolayer 单分子层
  • loaded 加负荷的
  • polyethylene 聚乙烯
  • lipid 脂质
  • hybrid 杂种
  • targeted 对准目标的
  • microscopy 显微镜检查
  • polymer 聚合物
  • shell 贝壳
  • core 岩心