A novel nanobody specific for respiratory surfactant protein A has potential for lung targeting
作者: Huiping LiXavier MuletPeng ZhangMin WuXian HeYaru WeiLiusheng WangJianhua HeShanmei WangZhaofang YinYang HuDong WengShanshan DuFeng YuGreg CoiaYukui DuNan Li
作者单位: 1Shanghai Pulmonary Hospital, Tongji University, School of Medicine
2Chinese Academy of Science
刊名: International Journal of Nanomedicine, 2015, Vol.2015 (default), pp.2857-2869
来源数据库: Dove Journal
DOI: 10.2147/IJN.S77268
原始语种摘要: The active lung-targeting drugs have long been thought to be a potential therapy of lung diseases, which can increase drug concentrations in the lung while reducing systemic side-effects. However, a major limitation in developing active lung-targeting drugs is the obtainment of specific lung-targeting molecules and ideal lung-targeting ligands. Pulmonary surfactant protein A (SPA) is predominantly synthesized by type II alveolar epithelial cells and therefore may serve as a specific target for the lung. Here, we generated recombinant rat pulmonary surfactant protein A (rSPA) as an antigen and immunized an alpaca to produce two nanobodies specific for rSPA, designated Nb6 and Nb17. To assess whether these nanobodies have the potential for lung-targeting, we evaluated their specificity to...
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影响因子:3.463 (2012)

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关键词翻译
关键词翻译
  • targeting 导向目标
  • potential 
  • protein 蛋白质
  • specific 
  • novel 长篇小说
  • affinity 亲和力
  • toxicity 毒性
  • generated 发生的
  • developing 显影
  • surfactant 表面活性剂