Polyetherimide-grafted Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging
作者: Yiyao LiuJie YanChengchen ZhangHongjun ZengYin ChenChunhui WuXue ShenHong YangTingting Li
作者单位: 1School of Life Science and Technology, University of Electronic Science an
刊名: International Journal of Nanomedicine, 2015, Vol.2015 (default), pp.4279-4291
来源数据库: Dove Journal
DOI: 10.2147/IJN.S85095
原始语种摘要: Engineering a safe and high efficiency delivery system for efficient RNA interference (RNAi) is critical for successful gene therapy. In this study, we designed a novel nano-carrier system of polyethyleneimine (PEI)-modified Fe3O4@SiO2, which allows high efficient loading of VEGF shRNA to form Fe3O4@SiO2/PEI/VEGF shRNA nanocomposites for VEGF gene silence as well as magnetic resonance (MR) imaging. The size, morphology, particle stability, magnetic property, and gene binding capacity and protection were determined. Low cytotoxicity and hemolyticity against human blood red cells showed the excellent biocompatibility of the multifunctional nanocomposites, and also no significant coagulation was observed. The nanocomposites maintain their superparamagnetic property at room temperature and no...
全文获取路径: Dove 
影响因子:3.463 (2012)

  • simultaneous 同时的
  • imaging 图像形成
  • efficient 有用的
  • resonance 共振
  • human 人的
  • magnetism 
  • delivery 移交
  • weight 
  • core 岩心
  • excellent 优秀的